Global Burden, Risk Factors, and Trends of Esophageal Cancer: An Analysis of Cancer Registries from 48 Countries

Cancers

Lin Zhang¹  Jinqiu Yuan²  Shanjuan Wang³  Wojciech Marlicz⁴  Ping Chen⁵  Zhi-Jie Zheng⁶  Veeleah Lok⁷  Anastasios Koulaouzidis⁸  Wanghong Xu⁹  ChunHo Ngai^1,10  ShellyL.A. Tse^1,10  Junjie Huang^1,10  Xiang-Qian Lao^1,10  MartinC.S. Wong^1,10  Cedric Chu^1,10  Shao-Hua Xie^1,11 

[1] Centre of Cancer Research, Victorian Comprehensive Cancer Centre, Melbourne, VIC 3000, Australia;Clinical Research Centre, Scientific Research Centre, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China;Department of Gastroenterology, Jiading District Hospital, Shanghai 201800, China;Department of Gastroenterology, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland;Department of Gastroenterology, Ruijing Hospital North, School of Medicine, Shanghai Jiaotong University, Shanghai 200240, China;Department of Global Health, School of Public Health, Peking University, Beijing 100191, China;Department of Global Public Health, Karolinska Institute, Karolinska University Hospital, 171 77 Stockholm, Sweden;Endoscopy Unit, The Royal Infirmary of Edinburgh, Edinburgh, Scotland EH4 2XU, UK;School of Public Health, Fudan University, Shanghai 200433, China;The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong SAR 999077, China;Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institute, Karolinska University Hospital, 171 77 Stockholm, Sweden;

关键词: esophageal cancer;    incidence;    mortality;    histological subtypes;    risk factors;   

DOI  :  10.3390/cancers13010141

来源: DOAJ

【 摘 要 】

This study aimed to examine the global burden, risk factors, and trends of esophageal cancer based on age, sex, and histological subtype. The data were retrieved from cancer registries database from 48 countries in the period 1980–2017. Temporal patterns of incidence and mortality were evaluated by average annual percent change (AAPC) using joinpoint regression. Associations with risk factors were examined by linear regression. The highest incidence of esophageal cancer was observed in Eastern Asia. The highest incidence of adenocarcinoma (AC) was found in the Netherlands, the United Kingdom, and Ireland. A higher AC/squamous cell carcinoma (SCC) incidence ratio was associated with a higher prevalence of obesity and elevated cholesterol. We observed an incidence increase (including AC and SCC) in some countries, with the Czech Republic (female: AAPC 4.66), Spain (female: 3.41), Norway (male: 3.10), Japan (female: 2.18), Thailand (male: 2.17), the Netherlands (male: 2.11; female: 1.88), and Canada (male: 1.51) showing the most significant increase. Countries with increasing mortality included Thailand (male: 5.24), Austria (female: 3.67), Latvia (male: 2.33), and Portugal (male: 1.12). Although the incidence of esophageal cancer showed an overall decreasing trend, an increasing trend was observed in some countries with high AC/SCC incidence ratios. More preventive measures are needed for these countries.

【 授权许可】

Unknown