Inhibitory Effect of Sargassum fusiforme and Its Components on Replication of Respiratory Syncytial Virus In Vitro and In Vivo

Viruses

Jong-Soo Lee¹  Asela Weerawardhana¹  Niranjan Dodantenna¹  Kiramage Chathuranga¹  Lakmal Ranathunga¹  Won-Kyung Cho²  JinYeul Ma² 

[1] College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea;Korean Medicine Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Korea;

关键词: Sargassum fusiforme;    RSV;    therapeutic effects;    eicosane;    docosane;    tetracosane;   

DOI  :  10.3390/v13040548

来源: DOAJ

【 摘 要 】

Sargassum fusiforme, a plant used as a medicine and food, is regarded as a marine vegetable and health supplement to improve life expectancy. Here, we demonstrate that S. fusiforme extract (SFE) has antiviral effects against respiratory syncytial virus (RSV) in vitro and in vivo mouse model. Treatment of HEp2 cells with a non-cytotoxic concentration of SFE significantly reduced RSV replication, RSV-induced cell death, RSV gene transcription, RSV protein synthesis, and syncytium formation. Moreover, oral inoculation of SFE significantly improved RSV clearance from the lungs of BALB/c mice. Interestingly, the phenolic compounds eicosane, docosane, and tetracosane were identified as active components of SFE. Treatment with a non-cytotoxic concentration of these three components elicited similar antiviral effects against RSV infection as SFE in vitro. Together, these results suggest that SFE and its potential components are a promising natural antiviral agent candidate against RSV infection.

【 授权许可】

Unknown