An Overview of Recent Advancements in Microbial Polyhydroxyalkanoates (PHA) Production from Dark Fermentation Acidogenic Effluents: A Path to an Integrated Bio-Refinery

Polymers

Sikandar I. Mulla¹  Si-Kyung Cho²  Gajanan S. Ghodake²  Ram Naresh Bharagava³  Dong-Su Kim⁴  Ganesh Dattatraya Saratale⁵  Han-Seung Shin⁵  Manu Kumar⁶  Ramasubba Reddy Palem⁷  Sunita Varjani⁸  Rijuta Ganesh Saratale⁹  Avinash A. Kadam⁹ 

[1] Department of Biochemistry, School of Applied Sciences, REVA University, Bangalore 560 064, India;Department of Biological and Environmental Science, Dongguk University, Ilsandong-gu, Goyang-si 10326, Gyonggido, Korea;Department of Environmental Microbiology, School for Environmental Sciences Babasaheb Bhimrao Ambedkar University, Vidya Vihar 226 025, Uttar Pradesh, India;Department of Environmental Science and Engineering, Ewha Womans University, Seoul 03760, Korea;Department of Food Science and Biotechnology, Dongguk University-Seoul, Ilsandong-gu, Goyang-si 10326, Gyeonggido, Korea;Department of Life Science, Dongguk University-Seoul, 32 Dongguk-ro, Ilsandong-gu, Goyang-si 10326, Gyeonggi-do, Korea;Department of Medical Biotechnology, Dongguk University Biomedical, Campus 32, Seoul 10326, Korea;Gujarat Pollution Control Board, Gandhinagar 382 010, Gujarat, India;Research Institute of Biotechnology and Medical Converged Science, Dongguk University-Seoul, Ilsandong-gu, Goyang-si 10326, Gyeonggido, Korea;

关键词: dark fermentative hydrogen production;    volatile fatty acids (VFAs);    polyhydroxyalkanoates (PHA);    biobased production;    genetic engineering;   

DOI  :  10.3390/polym13244297

来源: DOAJ

【 摘 要 】

Global energy consumption has been increasing in tandem with economic growth motivating researchers to focus on renewable energy sources. Dark fermentative hydrogen synthesis utilizing various biomass resources is a promising, less costly, and less energy-intensive bioprocess relative to other biohydrogen production routes. The generated acidogenic dark fermentative effluent [e.g., volatile fatty acids (VFAs)] has potential as a reliable and sustainable carbon substrate for polyhydroxyalkanoate (PHA) synthesis. PHA, an important alternative to petrochemical based polymers has attracted interest recently, owing to its biodegradability and biocompatibility. This review illustrates methods for the conversion of acidogenic effluents (VFAs), such as acetate, butyrate, propionate, lactate, valerate, and mixtures of VFAs, into the value-added compound PHA. In addition, the review provides a comprehensive update on research progress of VFAs to PHA conversion and related enhancement techniques including optimization of operational parameters, fermentation strategies, and genetic engineering approaches. Finally, potential bottlenecks and future directions for the conversion of VFAs to PHA are outlined. This review offers insights to researchers on an integrated biorefinery route for sustainable and cost-effective bioplastics production.

【 授权许可】

Unknown