Mature T-Cell leukemias: Challenges in Diagnosis

Frontiers in Oncology

Claire Dearden¹  Ayoma Attygalle²  Dima El-Sharkawi³ 

[1] Department of Haematology, The Royal Marsden NHS Foundation Trust, London, United Kingdom;Department of Histopathology, The Royal Marsden NHS Foundation Trust, London, United Kingdom;Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom;

关键词: diagnostics;    mature T and NK-cell neoplasms;    T-PLL;    T-cell prolymphocytic leukemia;    large granular lymphocyte (LGL) leukemia;    adult T-cell leukemia/lymphoma (ATL);   

DOI  :  10.3389/fonc.2022.777066

来源: DOAJ

【 摘 要 】

T-cell clones can frequently be identified in peripheral blood. It can be difficult to appreciate whether these are benign and transient or whether they signify a clonal disorder. We review factors that aid in understanding the relevance of T-cell clones. Conversely, obvious pathological T-cell clones can be detected in blood, but there is uncertainty in how to categorize this clonal T cell population, thus, we adopt a multidisciplinary review of the clinical features, diagnostic material and radiology before making the diagnosis. In this review we shall discuss some of these challenges faced when diagnosing mature T-cell leukemias.

【 授权许可】

Unknown