“T-cell prolymphocytic leukemia (T-PLL), a heterogeneous disease exemplified by two cases and the important role of cytogenetics: a multidisciplinary approach”

Experimental Hematology & Oncology

Nagesh Rao¹  Paul Delgado²  Phillip Starshak¹  Carlos A Tirado¹ 

[1] Department of Pathology & Laboratory Medicine, David Geffen UCLA School of Medicine, Los Angeles, CA, 90095, USA;Department of Ecology and Evolutionary Biology, UCLA, Los Angeles, CA, 90095, USA

关键词: FISH;    Cytogenetics;    T-PLL;   

Others  :  814722
DOI  :  10.1186/2162-3619-1-21

 received in 2012-07-21, accepted in 2012-08-16,  发布年份 2012

【 摘 要 】

T-cell prolymphocytic leukemia (T-PLL) is a rare form of leukemia composed of mature T-cells that usually presents in older people with a median age of 65. Most cases of T-PLL will harbor chromosomal abnormalities involving 14q11.2 (TCR alpha/delta), 14q32 (TCL1) or Xq28 (MTCP-1), abnormalities of chromosome 8, 12p and deletions of the long arm of chromosomes 5, 6, 11 and 13. Cytogenetics, FISH, comparative genomic hybridization (CGH) , SNP arrays with high resolution analysis have provided more precisely frequent submicroscopic gene and genomic lesions as well as breakpoints involved in the pathogenesis of this disease. One of the cornerstones to diagnose T-PLL are cytogenetic analysis. Here we summarize the current cytogenetic findings and we also describe two distinct cases of T-PLL where cytogenetics, FISH , morphologic analysis and flow cytometry helped to diagnose them accurately.

【 授权许可】

   
2012 Tirado et al.; licensee BioMed Central Ltd.

【 图 表 】

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