Metformin Intervention—A Panacea for Cancer Treatment?

Cancers

Adam Jacek Krętowski¹  Angelika Buczyńska¹  Iwona Sidorkiewicz¹  Agnieszka Adamska²  Monika Zbucka-Krętowska³ 

[1]Clinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, Poland

[2]Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland

[3]Department of Gynecological Endocrinology and Adolescent Gynecology, Medical University of Bialystok, 15-276 Bialystok, Poland

关键词: metformin;    antioxidant;    anti-cancer;   

DOI  :  10.3390/cancers14051336

来源: DOAJ

【 摘 要 】

The molecular mechanism of action and the individual influence of various metabolic pathways related to metformin intervention are under current investigation. The available data suggest that metformin provides many advantages, exhibiting anti-inflammatory, anti-cancer, hepatoprotective, cardioprotective, otoprotective, radioprotective, and radio-sensitizing properties depending on cellular context. This literature review was undertaken to provide novel evidence concerning metformin intervention, with a particular emphasis on cancer treatment and prevention. Undoubtedly, the pleiotropic actions associated with metformin include inhibiting inflammatory processes, increasing antioxidant capacity, and improving glycemic and lipid metabolism. Consequently, these characteristics make metformin an attractive medicament to translate to human trials, the promising results of which were also summarized in this review.

【 授权许可】

Unknown