The Regulation and Role of piRNAs and PIWI Proteins in Cancer

Processes

Ayoung Jeong¹  Kyung Won Kim¹  Hyeseon Jeong¹  Kyung Hwan Park¹  Sooji Choi¹  Yuri Lee¹ 

[1] Department of Life Science, Hallym University, Chuncheon 24252, Korea;

关键词: piRNA;    PIWI;    PIWIL;    small RNA;    non-coding RNA;    cancer;   

DOI  :  10.3390/pr9071208

来源: DOAJ

【 摘 要 】

P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are regulatory small non-coding RNAs that participate in transposon inactivation, chromatin regulation, and endogenous gene regulation. Numerous genetic and epigenetic factors regulate cell proliferation and tumor metastasis. PIWI proteins and piRNAs have been revealed to function in regulating upstream or downstream of oncogenes or tumor-suppressor genes in cancer tissues. In the present review, we summarize major recent findings in uncovering the regulation and role of PIWI proteins and piRNAs in tumorigenesis and highlight some of the promising applications of specific piRNAs in cancer therapeutics and as cancer biomarkers.

【 授权许可】

Unknown