Association of the mean platelet volume and red cell distribution width with dipper and non-dipper blood pressure in prehypertensive non-smokers

BMC Research Notes

Pantea Nazarpoori¹  Mohammadreza Taban Sadeghi¹  Saeideh Aghayari Sheikh Neshin²  Zahra Soroureddin³  Masoud Nouri-Vaskeh⁴ 

[1] Cardiovascular Research Center, Tabriz University of Medical Sciences;Faculty of Medicine, Guilan University of Medical Sciences;Faculty of Medicine, Shahid Beheshti University of Medical Sciences;Immunology Research Center, Tabriz University of Medical Sciences;

关键词: Blood pressure;    Dipper;    Mean platelet volume;    Prehypertension;    Red blood cell distribution width;   

DOI  :  10.1186/s13104-019-4868-x

来源: DOAJ

【 摘 要 】

Abstract Objective Absence of nocturnal blood pressure (BP) dipping is associated with poor health outcomes, including increased mortality. Non-dipper BP seems to be a predictor of cardiovascular damage in hypertensive patients. The aim of this study was to investigate the association of the mean platelet volume (MPV) and red cell distribution width (RDW) with nocturnal dipping/non dipping status in newly diagnosed and untreated prehypertensive non-smokers, using ambulatory BP monitoring. Results Twenty-eight patients (15 males) in the dipper group and 24 patients (11 males) in the non-dipper group were evaluated in this study. The age of patients was 41.64 ± 15.01 and 37.96 ± 15.08 years in the dipper and non-dipper groups, respectively. The rate of nocturnal systolic BP drop in the dipper and non-dipper groups was 13.79 ± 3.35% (10.20–22.10) and 5.96 ± 2.87% (1.10–9.30) (P < 0.001), respectively. Also, the mean rate of nocturnal diastolic BP drop in the dipper and non-dipper groups was 17.02 ± 5.09% (10.30–26.90) and 6.19 ± 2.75% (1.20–9.70) (P < 0.001), respectively. RDW and MPV were significantly higher in non-dipper patients than dipper patients (P = 0.001 and P = 0.012, respectively). Bivariate analysis revealed that MPV was inversely correlated with the nocturnal systolic BP drop (P = 0.005, r = − 0.385). Furthermore, RDW was inversely correlated with systolic BP drop (P = 0.019, r = − 0.324).

【 授权许可】

Unknown