Relationship between prehypertension and chronic kidney disease in middle-aged people in Korea: the Korean genome and epidemiology study

BMC Public Health

Hyun-Young Park¹  Nam-Kyoo Lim¹  Min-Ju Kim¹ 

[1] Division of Cardiovascular and Rare Diseases, Center for Biomedical Science, National Institute of Health, Chungbuk, South Korea

关键词: Estimated glomerular filtration rate;    Prehypertension;    Chronic kidney disease;    Blood pressure;   

Others  :  1162868
DOI  :  10.1186/1471-2458-12-960

 received in 2012-02-15, accepted in 2012-10-25,  发布年份 2012

【 摘 要 】

Background

Elevated blood pressure (BP) is a major risk factor for the progression of chronic kidney disease (CKD). However, little is known about the influence of prehypertension on CKD. In this study, we investigated the relationship between prehypertension and CKD in a middle-aged Korean population. Furthermore, we prospectively evaluated the effect of active BP control on deterioration of kidney function during the two-year follow-up.

Methods

The Korean Genome and Epidemiology Study is a community-based prospective cohort study started in 2001, with a follow-up survey conducted every two years. A total of 9509 participants aged 40–69 years were included in a baseline study. BP was classified according to the Seventh Report of the Joint National Committee on High BP (JNC-7) categories and CKD was defined as the presence of proteinuria or eGFR< 60mL/min/1.73m². A multivariable logistic regression model was used to identify associations between BP and CKD.

Results

The overall prevalence of CKD was 13.2%, and significantly increased with BP level. The multivariable-adjusted odds ratio of CKD was 1.59 for prehypertension and 2.27 for hypertension, compared with a normal BP. At the two-year follow-up, among the participants with prehypertension, subjects whose BP was poorly controlled had a significantly higher risk of eGFR drop (OR, 1.37; 95% CI, 1.13-1.67), as compared to controls. The prevalence of eGFR drop was 57.8% in the controlled BP group and 66.0% in the poorly-controlled BP group.

Conclusions

Prehypertension, as well as hypertension, is significantly associated with CKD among middle-aged Koreans. Our results indicate that active control of the blood-pressure of prehypertensive individuals is needed to prevent deterioration of kidney function.

【 授权许可】

   
2012 Kim et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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