Backstage of Eating Disorder—About the Biological Mechanisms behind the Symptoms of Anorexia Nervosa

Nutrients

Magdalena Kurnik-Łucka¹  Kamil Skowron¹  Emil Dadański¹  Krzysztof Gil¹  Barbara Bętkowska-Korpała² 

[1] Department of Pathophysiology, Jagiellonian University Medical College, Czysta St 18, 31-121 Krakow, Poland;Department of Psychiatry, Jagiellonian University Medical College, Institute of Medical Psychology, Jakubowskiego St 2, 30-688 Krakow, Poland;

关键词: anorexia nervosa;    eating disorders;    starvation;    hyperactivity;    neuropeptides;    microbiome–gut–brain axis;   

DOI  :  10.3390/nu12092604

来源: DOAJ

【 摘 要 】

Anorexia nervosa (AN) represents a disorder with the highest mortality rate among all psychiatric diseases, yet our understanding of its pathophysiological components continues to be fragmentary. This article reviews the current concepts regarding AN pathomechanisms that focus on the main biological aspects involving central and peripheral neurohormonal pathways, endocrine function, as well as the microbiome–gut–brain axis. It emerged from the unique complexity of constantly accumulating new discoveries, which hamper the ability to look at the disease in a more comprehensive way. The emphasis is placed on the mechanisms underlying the main symptoms and potential new directions that require further investigation in clinical settings.

【 授权许可】

Unknown