The Osteogenic Potential of Brown Seaweed Extracts

Marine Drugs

Steven McKelvey¹  Gary Sheldrake²  SusanA. Clarke²  PamelaJ. Walsh²  Susan McGrath³  Lauren Ford⁴ 

[1] Biomedical Science, Queen’s University Belfast 97 Lisburn Road, Belfast BT9 7BL, UK;School of Chemistry and Chemical Engineering, Queen’s University Belfast, David Keir Building, Stranmillis Road, Belfast BT9 5AG, UK;;School of Medicine, Dentistry &School of Nursing and Midwifery, Queen’s University Belfast, MBC, 97 Lisburn Road, Belfast BT9 7BL, UK;

关键词: brown seaweeds;    fucoxanthin;    osteogenic;    bone regeneration;    osteoporosis;   

DOI  :  10.3390/md17030141

来源: DOAJ

【 摘 要 】

Marine drugs hold significantly more promise than their terrestrial counterparts, which could help to solve the current shortfall in treatments for osteoporosis and other bone related diseases. Fucoxanthin is the main carotenoid found in brown seaweed, and has many perceived health benefits, including potential bone therapeutic properties. This study assessed the osteogenic potential of pure fucoxanthin and crude extracts containing both fucoxanthin and phenolic fractions (also cited to have osteogenic potential) isolated from two intertidal species of brown seaweed, Laminaria digitata and Ascophyllum nodosum. In vitro studies were performed using a human foetal osteoblast cell line (hFOBs) and primary human bone marrow stromal cells (hBMSCs). The results found pure fucoxanthin inhibitory to cell proliferation in hFOBs at higher concentrations, whereas, the crude extracts containing both polyphenols and fucoxanthin showed the ability to scavenge free radicals, which masked this effect. None of the extracts tested showed strong pro-osteogenic effects in either cell type tested, failing to support previously reported positive effects.

【 授权许可】

Unknown