Current research status of the mechanism of age-related macular degeneration parainflammation

Guoji Yanke Zazhi

Ping-Hua Li¹  Xuan-Li Liu¹ 

[1]Department of Ophthalmology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

关键词: AMD;    parainflammation;    complement;    gene;    ROS;    ROS;   

DOI  :  10.3980/j.issn.1672-5123.2014.03.18

来源: DOAJ

【 摘 要 】

Age-related macular degeneration(AMD)is a multifactorial- and polygenic-mediated chronic degenerative disease. Parainflammation is defined as a condition of tissue adaptive response to noxious stress or malfunction, it has features which are considered as intermediate between normal/basal and inflammatory/acute states. With the genetic predispositions, increased reactive oxygen species(ROS)generation cause the complement activation, placing the neuroretina-pigment epithelium-Bruch's membrane-choriocapillaris(NR-RPE-MB-CC)in the chronic condition of parainflammation which mediate apoptosis and angiogenesis, leading to AMD.

【 授权许可】

Unknown