Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning

International Journal of Molecular Sciences

DerekJ. Hausenloy¹  Lucia Cugusi²  Pasquale Pagliaro³  Claudia Penna³  Manuela Aragno³  Antonio Crisafulli⁴  Silvana Roberto⁴  Giuseppe Mercuro⁴  Luc Bertrand⁵  Christophe Beauloye⁶  Antigone Lazou⁶ 

[1] Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore, Singapore 169857, Singapore;Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy;Department of Clinical and Biological Science, University of Torino, 10043 Obassano (TO), Italy;Department of Medical Sciences and Public Health, University of Cagliari, 09124 Cagliari, Italy;Pole of Cardiovascular Research, IREC Institute, UCLouvain, 1200 Brussels, Belgium;School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece;

关键词: diabetic cardiomyopathy;    hyperglycemia;    ischemia/reperfusion injury;    metabolism;    mitochondria;    remote conditioning;   

DOI  :  10.3390/ijms21082896

来源: DOAJ

【 摘 要 】

Metabolic syndrome, diabetes, and ischemic heart disease are among the leading causes of death and disability in Western countries. Diabetic cardiomyopathy is responsible for the most severe signs and symptoms. An important strategy for reducing the incidence of cardiovascular disease is regular exercise. Remote ischemic conditioning has some similarity with exercise and can be induced by short periods of ischemia and reperfusion of a limb, and it can be performed in people who cannot exercise. There is abundant evidence that exercise is beneficial in diabetes and ischemic heart disease, but there is a need to elucidate the specific cardiovascular effects of emerging and unconventional forms of exercise in people with diabetes. In addition, remote ischemic conditioning may be considered among the options to induce beneficial effects in these patients. The characteristics and interactions of diabetes and ischemic heart disease, and the known effects of exercise and remote ischemic conditioning in the presence of metabolic syndrome and diabetes, are analyzed in this brief review.

【 授权许可】

Unknown