Evolving Insights Into the Biological Function and Clinical Significance of Long Noncoding RNA in Glioblastoma

Frontiers in Cell and Developmental Biology

Liping Jiang¹  Hong Chen²  Yi Li²  Yuanyuan Wang³  Kun Liu⁴ 

[1] Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL, United States;Department of Oncology, 920th Hospital of Joint Logistics Support Force, Teaching Hospital of Kunming Medical University, Kunming, China;Department of Pathology, 920th Hospital of Joint Logistics Support Force, Teaching Hospital of Kunming Medical University, Kunming, China;Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States;Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, China;

关键词: lncRNA;    glioblastoma;    diagnostic biomarker;    prognostic biomarker;    targeted therapy;   

DOI  :  10.3389/fcell.2022.846864

来源: DOAJ

【 摘 要 】

Glioblastoma (GBM) is one of the most prevalent and aggressive cancers worldwide. The overall survival period of GBM patients is only 15 months even with standard combination therapy. The absence of validated biomarkers for early diagnosis mainly accounts for worse clinical outcomes of GBM patients. Thus, there is an urgent requirement to characterize more biomarkers for the early diagnosis of GBM patients. In addition, the detailed molecular basis during GBM pathogenesis and oncogenesis is not fully understood, highlighting that it is of great significance to elucidate the molecular mechanisms of GBM initiation and development. Recently, accumulated pieces of evidence have revealed the central roles of long noncoding RNAs (lncRNAs) in the tumorigenesis and progression of GBM by binding with DNA, RNA, or protein. Targeting those oncogenic lncRNAs in GBM may be promising to develop more effective therapeutics. Furthermore, a better understanding of the biological function and underlying molecular basis of dysregulated lncRNAs in GBM initiation and development will offer new insights into GBM early diagnosis and develop novel treatments for GBM patients. Herein, this review builds on previous studies to summarize the dysregulated lncRNAs in GBM and their unique biological functions during GBM tumorigenesis and progression. In addition, new insights and challenges of lncRNA-based diagnostic and therapeutic potentials for GBM patients were also introduced.

【 授权许可】

Unknown