The Roles of Exosomes as Future Therapeutic Agents and Diagnostic Tools for Glioma

Frontiers in Oncology

Xiaoben Wu¹  Xin Wang¹  Zhiming Lu¹  Yingying Hao¹  Fang Liu¹  Jing Wang¹  Lei Yang²  Xingbang Wang³ 

[1] Department of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China;Department of Medical Engineering, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China;Department of Neurology, Qilu Hospital, Shandong University, Jinan, China;

关键词: exosomes;    glioma;    diagnostic biomarker;    prognostic biomarker;    treatment;   

DOI  :  10.3389/fonc.2021.733529

来源: DOAJ

【 摘 要 】

Glioma is a common type of tumor originating in the brain. Glioma develops in the gluey supporting cells (glial cells) that surround and support nerve cells. Exosomes are extracellular vesicles that contain microRNAs, messenger RNA, and proteins. Exosomes are the most prominent mediators of intercellular communication, regulating, instructing, and re-educating their surrounding milieu targeting different organs. As exosomes’ diameter is in the nano range, the ability to cross the blood–brain barrier, a crucial obstacle in developing therapeutics against brain diseases, including glioma, makes the exosomes a potential candidate for delivering therapeutic agents for targeting malignant glioma. This review communicates the current knowledge of exosomes’ significant roles that make them crucial future therapeutic agents and diagnostic tools for glioma.

【 授权许可】

Unknown