Early-life exposure to endocrine disrupting chemicals associates with childhood obesity

Annals of Pediatric Endocrinology & Metabolism

Alice Pik Shan Kong¹  Lee Ling Lim¹  Hin Kiu Lee²  Zongwei Cai²  Arthur C.K. Chung²  Chunxue Yang² 

[1] Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China;State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong SAR, China;

关键词: Endocrine disrupting chemicals;    Childhood obesity;    Persistent organic pollutants;    Early-life exposure;   

DOI  :  10.6065/apem.2018.23.4.182

来源: DOAJ

【 摘 要 】

Increasing prevalence of childhood obesity poses threats to the global health burden. Because this rising prevalence cannot be fully explained by traditional risk factors such as unhealthy diet and physical inactivity, early-life exposure to endocrine disrupting chemicals (EDCs) is recognized as emerging novel risk factors for childhood obesity. EDCs can disrupt the hormone-mediated metabolic pathways, affect children’s growth and mediate the development of childhood obesity. Many organic pollutants are recently classified to be EDCs. In this review, we summarized the epidemiological and laboratory evidence related to EDCs and childhood obesity, and discussed the possible mechanisms underpinning childhood obesity and early-life exposure to non-persistent organic pollutants (phthalates, bisphenol A, triclosan) and persistent organic pollutants (dichlorodiphenyltrichloroethane, polychlorinated biphenyls, polybrominated diphenyl ethers, per- and polyfluoroalkyl substances). Understanding the relationship between EDCs and childhood obesity helps to raise public awareness and formulate public health policy to protect the youth from exposure to the harmful effects of EDCs.

【 授权许可】

Unknown