Endothelial Function in Healthy Young Individuals Is Associated with Dietary Consumption of Saturated Fat

Frontiers in Physiology

John B. Dixon²  Regina Belski³  Ainura Tursunalieva⁴  Markus Schlaich⁵  Nora Straznicky⁶  Mariee Grima⁶  Carolina I. Sari⁶  Gavin W. Lambert⁷  Sarah Phillips⁷  Nina Eikelis⁷  Elisabeth A. Lambert⁷  Geoffrey A. Head⁸ 

[1] Clinical Obesity Research Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia;Department of General Practice, Monash University, Clayton, VIC, Australia;Department of Health Professions, School of Health Science, Swinburne University of Technology, Hawthorn, VIC, Australia;Department of Statistics Data Science and Epidemiology, School of Health Science, Swinburne University of Technology, Hawthorn, VIC, Australia;Dobney Hypertension Centre, School of Medicine—Royal Perth Hospital Unit, University of Western Australia, Perth, WA, Australia;Faculty of Health, Arts and Design, Iverson Health Innovation Research Institute, Swinburne University of Technology, Hawthorn, VIC, Australia;Human Neurotransmitters Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia;Neuropharmacology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia;

关键词: diet;    saturated fat;    endothelial function;    overweight;    cardiovascular risk;   

DOI  :  10.3389/fphys.2017.00876

来源: DOAJ

【 摘 要 】

Background: A diet rich in fat, in particular saturated fat (SF), may be linked to cardiovascular disease development, possibly due to a detrimental effect of fat on endothelial function (EF).Objective: We aimed to determine whether the habitual SF intake [as a ratio to total fat (the sum of saturated, polyunsaturated, and monounsaturated fat)] might influence endothelial function in young, overweight but otherwise healthy adults.Design: Sixty-nine young adults (49 males, mean age: 23 ± 1 years, mean BMI: 29.1 ± 0.8 kg/m2) were classified into three tertiles according to their habitual SF intake consumption (low SF: <39%, medium SF 39.1–43.7%, and high SF: >43.7% of total fat). Endothelial function was assessed using digital amplitude tonometry.Results: The three groups of individuals were comparable for total energy intake and calories from: fat, protein, and carbohydrates. There was no difference in anthropometric and hemodynamic variables among the groups. Those in the high SF group presented with impaired endothelial function [reactive hyperemia index (RHI): high SF: 1.60 ± 0.08 compared to 2.23 ± 0.16 in the medium SF and 2.12 ± 0.14 in the low SF group, P < 0.01]. Regression analysis, including gender, age, ethnicity, body mass index indicated that the ratio of SF to total fat was an independent predictor of the RHI (P < 0.05).Conclusion: The habitual consumption of a diet high in SF in relation to polyunsaturated and monounsaturated fat was strongly associated with impaired endothelial function in young overweight adults, potentially contributing to increased risk of developing cardiovascular disease.

【 授权许可】

Unknown