Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer’s Disease

International Journal of Molecular Sciences

Jieqiong Tan¹  King-Ho Cheung²  Yuxuan Kan²  Min Li²  Zhou Zhu²  Chengfu Su²  Jia Liu²  Xinjie Guan²  Ashok Iyaswamy²  Sravan Gopalkrishnashetty Sreenivasmurthy²  Jiahong Lu³ 

[1] Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410000, China;Mr. & Mrs. Ko Chi-Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China;State Key Lab of Quality Research in Chinese Medicine, University of Macau, Macao, China;

关键词: Alzheimer’s disease;    selective autophagy;    aggrephagy;    mitophagy;    reticulophagy;    lipophagy;   

DOI  :  10.3390/ijms23073609

来源: DOAJ

【 摘 要 】

Eukaryotic cells possess a plethora of regulatory mechanisms to maintain homeostasis and ensure proper biochemical functionality. Autophagy, a central, conserved self-consuming process of the cell, ensures the timely degradation of damaged cellular components. Several studies have demonstrated the important roles of autophagy activation in mitigating neurodegenerative diseases, especially Alzheimer’s disease (AD). However, surprisingly, activation of macroautophagy has not shown clinical efficacy. Hence, alternative strategies are urgently needed for AD therapy. In recent years, selective autophagy has been reported to be involved in AD pathology, and different subtypes have been identified, such as aggrephagy, mitophagy, reticulophagy, lipophagy, pexophagy, nucleophagy, lysophagy and ribophagy. By clarifying the underlying mechanisms governing these various subtypes, we may come to understand how to control autophagy to treat AD. In this review, we summarize the latest findings concerning the role of selective autophagy in the pathogenesis of AD. The evidence overwhelmingly suggests that selective autophagy is an active mechanism in AD pathology, and that regulating selective autophagy would be an effective strategy for controlling this pathogenesis.

【 授权许可】

Unknown