Memory consolidation during sleep and adult hippocampal neurogenesis

Neural Regeneration Research

关键词: rapid eye movement sleep;    sleep deprivation;    optogenetics;    real-time sleep analysis;    hippocampus;    fear memory;    synaptic plasticity;    memory processing;   

DOI  :  10.4103/1673-5374.243695

来源: DOAJ

【 摘 要 】

In anticipation of the massive burden of neurodegenerative disease within super-aged societies, great efforts have been made to utilize neural stem and progenitor cells for regenerative medicine. The capacity of intrinsic neural stem and progenitor cells to regenerate damaged brain tissue remains unclear, due in part to the lack of knowledge about how these newly born neurons integrate into functional circuitry. As sizable integration of adult-born neurons naturally occurs in the dentate gyrus region of the hippocampus, clarifying the mechanisms of this process could provide insights for applying neural stem and progenitor cells in clinical settings. There is convincing evidence of functional correlations between adult-born neurons and memory consolidation and sleep; therefore, we describe some new advances that were left untouched in our recent review.

【 授权许可】

Unknown