Myocardiocyte autophagy in the context of myocardiocytes regeneration: a potential novel therapeutic strategy

Egyptian Journal of Medical Human Genetics

Tatyana Ivanovna Vlasova¹  Basheer Abdullah Marzoog¹ 

[1] National Research Mordovia State University;

关键词: Autophagy and regeneration;    Myocardial infarction and myocardiocyte;    Pathogenesis and pathophysiology;    Molecular medicine;   

DOI  :  10.1186/s43042-022-00250-8

来源: DOAJ

【 摘 要 】

Abstract Background The regeneration strategy involves several aspects, such as reprogramming aspects, targeting pathophysiological processes, and inducing the physiological one. Autophagy targeting is a potential physiological/pathogenetic strategy to enhance myocardiocytes' function. Myocardiocytes' injury-related death remains to be the highest in our era. Unfortunately, myocardiocytes have a limited proliferation capacity to compensate for what was lost by infarction. However, partially injured myocardiocytes can be preserved by improving the autophagy process of myocardiocytes. Main text Autophagy induction involved controlling the cellular and subcellular environment as well as gene expression. Autophagy is well known to prolong the longevity of cell and human life. Inhibition of the mTOR receptor, proapoptotic gene Bnip3, IP3, and lysosome inhibitors, inhibition of microRNA-22 and overexpression of microRNA-99a, modulators of activated protein kinase with adenosine monophosphate, resveratrol, sirtuin activators, Longevinex and calcium lowering agents can promote physiological myocardiocyte autophagy and improve post-myocardial modulation and recovery speed. The paper aimed to assess autophagy role in myocardiocytes regeneration modulation. Conclusions The autophagy strategy can be applied to infarcted myocardiocytes, as well as heart failure. However, cell self-eating is not the preferred therapy for preserving injured myocardiocytes or causing regeneration.

【 授权许可】

Unknown