Simulations in Medicine and Biology: Insights and perspectives

3rd International Conference on Mathematical Modeling in Physical Sciences

物理学;数学

Spyrou, George M.^1

Biomedical Research Foundation of the Academy of Athens, Soranou Efessiou 4, Athens

115 27, Greece^1

关键词: Effective therapy;    Knowledge extraction;    Medical procedures;    Modelling and simulations;    Molecular medicine;    Multilevel optimization;    Real time monitoring;    Thermodynamic characteristics;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/574/1/012065/pdf
DOI  :  10.1088/1742-6596/574/1/012065

来源: IOP

【 摘 要 】

Modern medicine and biology have been transformed into quantitative sciences of high complexity, with challenging objectives. The aims of medicine are related to early diagnosis, effective therapy, accurate intervention, real time monitoring, procedures/systems/instruments optimization, error reduction, and knowledge extraction. Concurrently, following the explosive production of biological data concerning DNA, RNA, and protein biomolecules, a plethora of questions has been raised in relation to their structure and function, the interactions between them, their relationships and dependencies, their regulation and expression, their location, and their thermodynamic characteristics. Furthermore, the interplay between medicine and biology gives rise to fields like molecular medicine and systems biology which are further interconnected with physics, mathematics, informatics, and engineering. Modelling and simulation is a powerful tool in the fields of Medicine and Biology. Simulating the phenomena hidden inside a diagnostic or therapeutic medical procedure, we are able to obtain control on the whole system and perform multilevel optimization. Furthermore, modelling and simulation gives insights in the various scales of biological representation, facilitating the understanding of the huge amounts of derived data and the related mechanisms behind them. Several examples, as well as the insights and the perspectives of simulations in biomedicine will be presented.