The Phytochemical Potential for Brain Disease Therapy and the Possible Nanodelivery Solutions for Brain Access

Frontiers in Oncology

Aijie Li¹  Xue Xia¹  Runhan Liu²  Yang Liu²  Haoying Yang³  Zhouchun Chen³ 

[1] School of Pharmacy, Henan University, Kaifeng, China;;Henan Key Laboratory of Brain Targeted Bio-nanomedicine, School of Life Sciences &Henan-Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, China;

关键词: phytochemicals;    blood–brain barrier;    brain diseases;    nanodelivery;    therapeutics development;   

DOI  :  10.3389/fonc.2022.936054

来源: DOAJ

【 摘 要 】

Plant-derived phytochemicals have gifted humans with vast therapeutic potentials. Yet, the unique features of the blood–brain barrier significantly limit their accession to the target tissue and thus clinical translation in brain disease treatment. Herein, we explore the medicinal outcomes of both the rare examples of phytochemicals that can easily translocate across the blood–brain barrier and most of the phytochemicals that were reported with brain therapeutic effects, but a bizarre amount of dosage is required due to their chemical nature. Lastly, we offer the nanodelivery platform that is capable of optimizing the targeted delivery and application of the non-permeable phytochemicals as well as utilizing the permeable phytochemicals for boosting novel applications of nanodelivery toward brain therapies.

【 授权许可】

Unknown