Development of Novel Therapeutics Targeting the Blood–Brain Barrier: From Barrier to Carrier

Advanced Science

卷:8

Jennifer R. Gamble¹  William A. Banks²  Meng Zheng³  Olga Shimoni⁴  Ashley I. Bush⁵  Jia Li⁶  Bingyang Shi⁶ 

[1] Center for the Endothelium Vascular Biology Program Centenary Institute The University of Sydney Sydney New South Wales 2042 Australia;

[2] Geriatric Research Education and Clinical Center Veterans Affairs Puget Sound Health Care System and Division of Gerontology and Geriatric Medicine Department of Medicine University of Washington School of Medicine Seattle WA 98108 USA;

[3] Henan‐Macquarie University Joint Center for Biomedical Innovation School of Life Sciences Henan University Kaifeng Henan 475004 China;

[4] Institute for Biomedical Materials and Devices School of Mathematical and Physical Sciences Faculty of Science University of Technology Sydney Sydney New South Wales 2007 Australia;

[5] Melbourne Dementia Research Center The Florey Institute for Neuroscience and Mental Health The University of Melbourne Parkville Victoria 3052 Australia;

[6] School of Pharmacy Henan University Kaifeng 475001 China;

关键词: blood–brain barrier;    brain diseases;    drug delivery;    nanomedicine;    nanotechnology;   

DOI  :  10.1002/advs.202101090

来源: DOAJ

【 摘 要 】

Abstract The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from entering the brain. An intact BBB is also critical for the maintenance of normal neuronal function. In cerebral vascular diseases and neurological disorders, the BBB can be disrupted, contributing to disease progression. While restoration of BBB integrity serves as a robust biomarker of better clinical outcomes, the restrictive nature of the intact BBB presents a major hurdle for delivery of therapeutics into the brain. Recent studies show that the BBB is actively engaged in crosstalk between neuronal and the circulatory systems, which defines another important role of the BBB: as an interfacing conduit that mediates communication between two sides of the BBB. This role has been subject to extensive investigation for brain‐targeted drug delivery and shows promising results. The dual roles of the BBB make it a unique target for drug development. Here, recent developments and novel strategies to target the BBB for therapeutic purposes are reviewed, from both barrier and carrier perspectives.

【 授权许可】

Unknown