Adenovirus-associated acute conjunctivitis in Beijing, China, 2011–2013

BMC Infectious Diseases

Lijuan Chen¹  Yiwei Du¹  Yang Yang¹  Baiwei Liu¹  Quanyi Wang¹  Jie Li¹  Lei Jia¹  Haikun Qian¹  Changying Lin¹  Baoming Jiang²  Xiaoyan Lu² 

[1] Beijing Center for Disease Prevention and Control;Centers for Disease Control and Prevention;

关键词: Acute conjunctivitis;    Human adenovirus;    HAdV type;   

DOI  :  10.1186/s12879-018-3014-z

来源: DOAJ

【 摘 要 】

Abstract Background Human adenovirus (HAdV)-associated acute conjunctivitis is a common infectious disease and causes significant morbidity among residents in Beijing, China. However, little is known about the epidemiology and type distribution of acute adenoviral conjunctivitis in Beijing. Methods Acute conjunctivitis surveillance was conducted in 18 hospitals in Beijing from July through October during 2011–2013. HAdVs were detected by PCR from eye swab and types were determined by partial hexon and fiber gene sequencing. Risk factors associated with adenoviral conjunctivitis were analyzed. Results Of 876 conjunctivitis cases, 349 (39.8%) were HAdV positive. HAdV detection was most common in conjunctivitis patients aged 18–40 years; patients with contact history with a conjunctivitis case; patients with specimen collected on days 4–6 post symptom onset and patients who worked in food service as catering attendants. Fifteen types were identified among adenoviral conjunctivitis cases. Five HAdV types (HAdV-4, − 37, − 53, − 64 and − 8) accounted for 81.1% of all adenoviral conjunctivitis cases. HAdV-37, − 4 and − 53 were the most common types associated with adenoviral conjunctivitis in 2011, 2012 and 2013, respectively. Conclusion Multiple HAdV types were associated with acute conjunctivitis in Beijing. Predominant types associated with adenoviral conjunctivitis circulating in Beijing varied from year to year.

【 授权许可】

Unknown