Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease

International Journal of Molecular Sciences

Srinath Palakurthi¹  Sushesh Srivatsa Palakurthi¹  Brijesh M. Shah¹  Sharad Khare²  Tripti Khare² 

[1] Department of Pharmaceutical Sciences, Rangel College of Pharmacy, Texas A&M University, Kingsville, TX 78363, USA;Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, MO 65212, USA;

关键词: inflammatory bowel disease;    Crohn’s disease;    ulcerative colitis;    phytochemicals;    macromolecules;    inflammation;   

DOI  :  10.3390/ijms21113956

来源: DOAJ

【 摘 要 】

: Many synthetic drugs and monoclonal antibodies are currently in use to treat Inflammatory Bowel Disease (IBD). However, they all are implicated in causing severe side effects and long-term use results in many complications. Numerous in vitro and in vivo experiments demonstrate that phytochemicals and natural macromolecules from plants and animals reduce IBD-related complications with encouraging results. Additionally, many of them modify enzymatic activity, alleviate oxidative stress, and downregulate pro-inflammatory transcriptional factors and cytokine secretion. Translational significance of natural nanomedicine and strategies to investigate future natural product-based nanomedicine is discussed. Our focus in this review is to summarize the use of phytochemicals and macromolecules encapsulated in nanoparticles for the treatment of IBD and IBD-associated colorectal cancer.

【 授权许可】

Unknown