ERAP1 and HLA-C interaction in inflammatory bowel disease in the Spanish population:

Innate Immunity

PatriciaCastro-Santos¹ 

关键词: Crohn’s disease;    ERAP1;    HLA-C;    inflammatory bowel disease;    ulcerative colitis;   

DOI  :  10.1177/1753425917716527

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Large genome-wide analysis studies (GWAS) and meta-analyses have dramatically increased our knowledge of the genetic risk factors of inflammatory bowel disease (IBD), identifying at least 163 loci. The endoplasmic reticulum aminopeptidase-2 (ERAP2) gene has been reported as a potential candidate gene for IBD. GWAS have also shown the potential associations between ERAP single nucleotide polymorphisms (SNP) loci and susceptibility to several autoimmune diseases, and ERAP1 and ERAP2 polymorphisms are related to HLA class I-associated diseases, including ankylosing spondylitis and Behçet’s disease. Interestingly, these associations were confined to individuals carrying HLA class I-risk alleles. The aim of this study was to investigate the association of ERAP1 and ERAP2 SNPs with IBD in a Spanish population, analysing their possible interaction with specific HLA-C alleles to IBD susceptibility. A total of 367 individuals were divided into 216 IBD cases and 151 controls. SNP genotyping was performed using TaqM...

【 授权许可】

CC BY