Adsorptive square wave voltammetric determination of the antiviral drug valacyclovir on a novel sensor of copper microparticles–modified pencil graphite electrode

Arabian Journal of Chemistry

Ahmed H. Naggar¹  Hassan F. Askal²  Ibrahim H. Refaat²  Gamal A. Saleh²  Fatma A.M. Abdel-aal² 

[1] Chemistry Department, Faculty of Science, Al-Azhar University, Assiut Branch, 71524 Assiut, Egypt;Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, 71526 Assiut, Egypt;

关键词: Valacyclovir;    Copper microparticles–modified pencil graphite electrode;    Adsorptive square wave stripping voltammetry;    Tablets;   

DOI  :  10.1016/j.arabjc.2015.08.015

来源: DOAJ

【 摘 要 】

To overcome the well-known problems encountered with surface fouling of carbon electrodes that occurred with many compounds, we report a simple and rapid method for the preparation of a disposable sensor depending on electrodeposition of porous Cu-microparticles on pencil graphite electrode (Cu-PGE) that can be applied for sensing antiviral compound valacyclovir (VAL). The bare and porous Cu-modified pencil graphite electrodes were characterized by cyclic voltammetry and SEM. The porous Cu-modified pencil graphite electrode displayed distinct electrocatalytic activities in response to the electrochemical redox reaction of Cu2+ ion in the Cu-VAL complex. Adsorptive square wave stripping voltammetry (AdSWV) was used for the direct electrochemical determination of VAL. Under experimental conditions, the modified electrode had a linear response range from 2.0 × 10−9 M to 1.0 × 10−8 M VAL with a detection limit of 1.78 × 10−10 M. The procedure was applied to the assay of VAL in tablets with mean percentage recoveries of 100.28%. The porous Cu-modified pencil graphite electrode (Cu-PGE) is fabricated utilizing a simple single method, and at an extremely low cost with high stability, sensitivity and offering a promising tool for sensing VAL in quality control laboratories and in stability studies.

【 授权许可】

Unknown