Valacyclovir in the treatment of acute retinal necrosis

BMC Ophthalmology

Research Article

Simon RJ Taylor¹  Robin Hamilton²  Nitin Gupta²  Claire Y Hooper²  Sue L Lightman³  Jiten Morarji⁴  Lavnish Joshi⁵ 

[1] Division of Immunology & Inflammation, Faculty of Medicine, Imperial College London, London, UK;Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK;Moorfields Eye Hospital, London, UK;Moorfields Eye Hospital, London, UK;Moorfields Eye Hospital, London, UK;UCL Institute of Ophthalmology, London, UK;Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK;Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK;UCL Institute of Ophthalmology, London, UK;

关键词: Acute retinal necrosis;    Herpetic retinitis;    Acyclovir;    Valacyclovir;   

DOI  :  10.1186/1471-2415-12-48

 received in 2012-06-12, accepted in 2012-08-31,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundTo report the outcome of oral valacyclovir as the sole antiviral therapy for patients with acute retinal necrosis (ARN).MethodsThis study reports a retrospective, interventional case series of nine consecutive patients with ten eyes with newly diagnosed ARN treated with oral valacyclovir as the sole antiviral agent. Eight patients received oral valacyclovir 2 g tid (Valtrex, GlaxoSmithKline) and one patient with impaired renal function received oral 1 g tid. The main outcome measures were response to treatment, time to initial response to treatment, time to complete resolution of retinitis, best corrected visual acuity (BCVA) at final follow-up, retinal detachment and development of recurrent or second eye disease.ResultsRetinitis resolved in ten of ten (100%) affected eyes. The median time to initial detectable response was seven days and the median time to complete resolution was 21 days. A final BCVA of 20/40 or better was achieved in 6/10 (60%) of eyes. 3/10 eyes (30%) developed a retinal detachment. No patients developed either disease reactivation or second eye involvement over the course of the study (mean follow up 31 weeks, range 7 to 104 weeks).ConclusionsTreatment with oral valacyclovir as the sole antiviral therapy resulted in complete resolution of retinitis. Final BCVA and retinal detachment rate were comparable with previously reported outcomes for intravenous acyclovir.

【 授权许可】

CC BY   
© Taylor et al.; licensee BioMed Central Ltd. 2012