Bile cast nephropathy: when the kidneys turn yellow

Renal Replacement Therapy

Alissar El Chediak¹  Khaled Janom²  Sahar H. Koubar³ 

[1] Department of Internal Medicine, American University of Beirut;Department of Internal Medicine, Detroit Medical Center/Wayne State University;Department of Internal Medicine, Division of Nephrology, Faculty of Medicine, American University of Beirut;

关键词: Bile cast nephropathy;    Cholemic nephropathy;    Hyperbilirubinemia;    Extracorporeal therapy;   

DOI  :  10.1186/s41100-020-00265-0

来源: DOAJ

【 摘 要 】

Abstract Kidney injury is a common finding in patients with liver disease. Bile cast nephropathy (also known as cholemic nephropathy) is an overlooked cause of renal injury in patients with hyperbilirubinemia. It can occur as a result of the toxic effects of bilirubin and bile acids on the renal tubules via several mechanisms. Bile cast nephropathy has characteristic histopathological changes consisting of bilirubin cast deposition in the distal nephron along with tubular epithelial cell injury. Treatment is based on the reversal of liver injury. This review aims to describe bile cast nephropathy in terms of its clinical and morphological features and to shed light on diagnostic techniques. In addition, we present data on management of such nephropathy while reviewing all the reported cases of bile cast nephropathy.

【 授权许可】

Unknown