Interactions between Autophagy and DNA Viruses

Viruses

Tian-fei Yu¹  Shu-li Shao¹  Hai-chang Yin¹  Xin-jie Jiang¹  Peng-yu Xie¹  Wan-shu Sun¹ 

[1] College of Life Science and Agriculture Forestry, Qiqihar University, Qiqihar, Heilongjiang 161006, China;

关键词: autophagy;    DNA viruses;    interactions;    replication;    immunity;   

DOI  :  10.3390/v11090776

来源: DOAJ

【 摘 要 】

Autophagy is a catabolic biological process in the body. By targeting exogenous microorganisms and aged intracellular proteins and organelles and sending them to the lysosome for phagocytosis and degradation, autophagy contributes to energy recycling. When cells are stimulated by exogenous pathogenic microorganisms such as viruses, activation or inhibition of autophagy is often triggered. As autophagy has antiviral effects, many viruses may escape and resist the process by encoding viral proteins. At the same time, viruses can also use autophagy to enhance their replication or increase the persistence of latent infections. Here, we give a brief overview of autophagy and DNA viruses and comprehensively review the known interactions between human and animal DNA viruses and autophagy and the role and mechanisms of autophagy in viral DNA replication and DNA virus-induced innate and acquired immunity.

【 授权许可】

Unknown