Immunotopographical Differences of Human Skin

Frontiers in Immunology

Krisztián Gáspár¹  Dániel Törőcsik¹  Anikó Kapitány¹  Barbara Medgyesi¹  Zsolt Dajnoki¹  Andrea Szegedi¹  Zoltán Péter¹  Gabriella Béke¹  Tamás Bíró²  Zoltán Hendrik³  Szilárd Póliska⁵ 

[1] Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary;Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary;Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary;Division of Dermatological Allergology, Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary;Genomic Medicine and Bioinformatic Core Facility, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary;

关键词: antimicrobial peptides;    barrier function;    chemokines;    IL-17;    sebaceous glands;    skin;   

DOI  :  10.3389/fimmu.2018.00424

来源: DOAJ

【 摘 要 】

The immunological barrier of the healthy skin is considered to be unified on the whole body surface—however, recent indirect findings have challenged this dogma since microbial and chemical milieu (e.g., sebum, sweat, and pH) exhibit remarkable differences on topographically distinct skin areas. Therefore, in the present study, we performed whole transcriptomic and subsequent pathway analyses to assess differences between sebaceous gland rich (SGR) and sebaceous gland poor (SGP) regions. Here, we provide the first evidence that different skin regions exhibit a characteristic innate and adaptive immune and barrier milieu as we could detect significantly increased chemokine (CCL2, 3, 19, 20, 23, 24) and antimicrobial peptide (S100A7, A8, A9, lipocalin, β-defensin-2) expression, altered barrier (keratin 17, 79) functions, and a non-inflammatory Th17/IL-17 dominance in SGR skin compared to SGP. Regarding pro-inflammatory molecules (IL-1α, IL-6, IL-8, IL-33, TNF-α), similarly low levels were detected in both regions. Our data may explain the characteristic topographical localization of some immune-mediated and autoimmune skin disorders and we also propose that the term “healthy skin control sample,” widely used in experimental Dermatology, should only be accepted if researchers carefully specify the exact region of the healthy skin (along with the site of the diseased sample).

【 授权许可】

Unknown