Interleukin-17 (IL-17) Expression Is Reduced during Acute Myocardial Infarction: Role on Chemokine Receptor Expression in Monocytes and Their in Vitro Chemotaxis towards Chemokines

Toxins

Maria Troitskaya²  Anton Baysa²  Jarle Vaage¹  Kristin L. Sand²  Azzam A. Maghazachi² 

[1] Department of Emergency and Intensive Care at the Institute of Clinical Medicine, Oslo University Hospital, Oslo N-0424, Norway;Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo N-0317, Norway;

关键词: myocardial infarction;    IL-17;    monocytes;    chemokines;    chemokine receptors;   

DOI  :  10.3390/toxins4121427

来源: mdpi

【 摘 要 】

The roles of immune cells and their soluble products during myocardial infarction (MI) are not completely understood. Here, we observed that the percentages of IL-17, but not IL-22, producing cells are reduced in mice splenocytes after developing MI. To correlate this finding with the functional activity of IL-17, we sought to determine its effect on monocytes. In particular, we presumed that this cytokine might affect the chemotaxis of monocytes important for cardiac inflammation and remodeling. We observed that IL-17 tends to reduce the expression of two major chemokine receptors involved in monocyte chemotaxis, namely CCR2 and CXCR4. Further analysis showed that monocytes pretreated with IL-17 have reduced in vitro chemotaxis towards the ligand for CCR2, i.e., MCP-1/CCL2, and the ligand for CXCR4, i.e., SDF-1α/CXCL12. Our results support the possibility that IL-17 may be beneficial in MI, and this could be due to its ability to inhibit the migration of monocytes.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.