Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies

Emerging Infectious Diseases

关键词: Middle East respiratory syndrome coronavirus;    MERS;    neutralization;    hemagglutination;    lumazine synthase;    antibodies;   

DOI  :  10.3201/eid2605.190921

来源: DOAJ

【 摘 要 】

We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.

【 授权许可】

Unknown