Immunogenicity of The BNT162b2 COVID-19 mRNA and ChAdOx1 nCoV-19 Vaccines in Patients with Hemoglobinopathies

Vaccines

Adel M. Abuzenadah¹  Adel F. Al-Marzouki²  Salem M. Bahashwan²  Mohamad H. Qari²  Hatem M. Alahwal²  Osman O. Radhwi²  Abdullah Waheeb²  Ahmed S. Barefah²  Abdullah T. Almohammadi²  Hamza Jan²  Ashgan Almanzlawey³  Iuliana Denetiu³  Anwar M. Hashem⁴  Sawsan S. Alamri⁴ 

[1] Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21859, Saudi Arabia;Hematology Department, Faculty of Medicine, King Abdulaziz University, Jeddah 21859, Saudi Arabia;Hematology Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21859, Saudi Arabia;Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21859, Saudi Arabia;

关键词: BNT162b2;    ChAdOx1 nCoV-19;    COVID-19;    vaccine;    thalassemia;    sickle cell disease;   

DOI  :  10.3390/vaccines10020151

来源: DOAJ

【 摘 要 】

Introduction: Studies assessing immune responses following Pfizer-BioNTech BNT162b2 mRNA COVID-19 (Pfizer) and ChAdOx1 nCoV-19 AZD1222 (AstraZeneca) vaccines in patients with hemoglobinopathy are non-existent in the literature despite being thought at high risk of infection. Methods: Prospectively, we collected serum from patients with hemoglobinopathies at least 14 days post vaccine and measured neutralizing antibodies (nAb) in addition to binding antibodies using in-house assays. Results: All 66 participants mounted a significant binding antibody response (100%), but nAbs were detected in (56/66) post-vaccine with a rate of 84.5%. Age, gender, vaccine type, spleen status, hydroxyurea use, and hyperferritinemia did not affect the rate significantly. While 23/32 (71.8%) patients receiving only one dose of the vaccine were able to mount a positive response, 33/34 (97.05%) of those who had two doses of any vaccine type had a significant nAbs response. Patients who had anti-nucleocapsid (N), signifying asymptomatic infection in the past, were able to produce nAbs (31/31). No nAbs were detected in 10/35 (28.5%) patients with no anti-N antibodies. Conclusion: Our results provide supportive data when advising patients with hemoglobinopathy to receive COVID-19 vaccines and ensure booster doses are available for better immunity. Whenever available, measurement of nAb is recommended.

【 授权许可】

Unknown