Titanium Dioxide Nanoparticle-Biomolecule Interactions Influence Oral Absorption

Nanomaterials

Jae Ho Song¹  Jae-Min Oh¹  Kyoung-Min Kim¹  Hyoung-Jun Kim¹  Mi-Rae Jo²  Soo-Jin Choi²  Jin Yu² 

[1] Department of Chemistry and Medical Chemistry, Yonsei University, Wonju, Gangwondo 26493, Korea;Division of Applied Food System, Major of Food Science and Technology, Seoul Women’s University, Seoul 01797, Korea;

关键词: titanium dioxide;    interaction;    biomolecule;    oral absorption;    intestinal transport;   

DOI  :  10.3390/nano6120225

来源: DOAJ

【 摘 要 】

Titanium dioxide (TiO2) nanoparticles (NPs) have been widely applied in various industrial fields, such as electronics, packaging, food, and cosmetics. Accordingly, concerns about the potential toxicity of TiO2 NPs have increased. In order to comprehend their in vivo behavior and potential toxicity, we must evaluate the interactions between TiO2 NPs and biomolecules, which can alter the physicochemical properties and the fate of NPs under physiological conditions. In the present study, in vivo solubility, oral absorption, tissue distribution, and excretion kinetics of food grade TiO2 (f-TiO2) NPs were evaluated following a single-dose oral administration to rats and were compared to those of general grade TiO2 (g-TiO2) NPs. The effect of the interactions between the TiO2 NPs and biomolecules, such as glucose and albumin, on oral absorption was also investigated, with the aim of determining the surface interactions between them. The intestinal transport pathway was also assessed using 3-dimensional culture systems. The results demonstrate that slightly higher oral absorption of f-TiO2 NPs compared to g-TiO2 NPs could be related to their intestinal transport mechanism by microfold (M) cells, however, most of the NPs were eliminated through the feces. Moreover, the biokinetics of f-TiO2 NPs was highly dependent on their interaction with biomolecules, and the dispersibility was affected by modified surface chemistry.

【 授权许可】

Unknown