Molecular Basis of the Function of Transcriptional Enhancers

Cells

OlegV. Bylino¹  YuliiV. Shidlovskii¹  AiratN. Ibragimov¹ 

[1] Laboratory of Gene Expression Regulation in Development, Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov St., Moscow 119334, Russia;

关键词: enhancer;    promoter;    chromatin;    transcriptional bursting;    transcription factories;    enhancer RNA;   

DOI  :  10.3390/cells9071620

来源: DOAJ

【 摘 要 】

Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process, and the epigenetic control of gene expression. Thus, multiple molecular details of enhancer functioning were revealed. Here, we describe the recent data and models of molecular organization of enhancer-driven transcription.

【 授权许可】

Unknown