The Crosstalk of miRNA and Oxidative Stress in the Liver: From Physiology to Pathology and Clinical Implications

International Journal of Molecular Sciences

Till Wissniowski¹  Christian Mayr²  Tobias Kiesslich²  Pietro Di Fazio³  Eckhard Klieser⁴  Daniel Neureiter⁴  Matthias Ocker⁵ 

[1] Department of Gastroenterology and Endocrinology, Philipps University Marburg, 35043 Marburg, Germany;Department of Internal Medicine I, Paracelsus Medical University/Salzburger Landeskliniken (SALK), 5020 Salzburg, Austria;Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, 35043 Marburg, Germany;Institute of Pathology, Paracelsus Medical University/Salzburger Landeskliniken (SALK), 5020 Salzburg, Austria;Translational Medicine Oncology, Bayer AG, 13353 Berlin, Germany;

关键词: microrna;    oxidative stress;    metabolism;    physiology;    ash;    nafld;    nash;    hcc;    hcv;    hbv;   

DOI  :  10.3390/ijms20215266

来源: DOAJ

【 摘 要 】

The liver is the central metabolic organ of mammals. In humans, most diseases of the liver are primarily caused by an unhealthy lifestyle−high fat diet, drug and alcohol consumption- or due to infections and exposure to toxic substances like aflatoxin or other environmental factors. All these noxae cause changes in the metabolism of functional cells in the liver. In this literature review we focus on the changes at the miRNA level, the formation and impact of reactive oxygen species and the crosstalk between those factors. Both, miRNAs and oxidative stress are involved in the multifactorial development and progression of acute and chronic liver diseases, as well as in viral hepatitis and carcinogenesis, by influencing numerous signaling and metabolic pathways. Furthermore, expression patterns of miRNAs and antioxidants can be used for biomonitoring the course of disease and show potential to serve as possible therapeutic targets.

【 授权许可】

Unknown