Prediction of effective Lens position using anterior segment optical coherence tomography in Chinese subjects with angle closure

BMC Ophthalmology

Zaowen Wang¹  Yang Zhang¹  Yuzhou Wu¹  Ailing Bian¹  Shunhua Zhang¹  Yong Zhong¹ 

[1] Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences;

关键词: Primary angle closure Glaucoma;    Anterior segment optical coherence tomography;    Formula;    Effective Lens position;   

DOI  :  10.1186/s12886-021-02213-w

来源: DOAJ

【 摘 要 】

Abstract Purpose To assess the accuracy of biometric parameters measured by anterior segment optical coherence tomography (AS-OCT) and partial coherence interferometry (PCI) in prediction of effective lens position (ELP) compared with previous formulas in PACG patients. Methods 121 PACG eyes were randomly divided into training set (85 eyes) and validation set (36 eyes) with same procedure including AS-OCT, PCI, phacoemulsification and IOL implantation surgery. Preoperative anterior chamber depth (pre-ACD), scleral spur depth (SSD), scleral spur width (SSW), lens vault (LV) and cornea thickness (CT) were measured from AS-OCT image. Axial length (AL) and corneal power (K) were measured by PCI. All the 7 parameters were analyzed by multiple linear regression in training set and a statistic regression formula was developed. In validation set, one-way ANOVA was applied to compare the new regression formula with Sanders-Retzlaff-Kraff theoretic (SRK/T), Holladay 1, Haigis, and a regression formula developed in previous study. Results The coefficient of determination (R2) of different parameter combinations are 0.19 (pre-ACD, AL), 0.25 (AL, K) and 0.49 (SSD, AL, SSW) in training set. In validation set, the correlation between predicted and measured ELP are: new formula (R2 = 0.50, P = 0.9947) Holladay 1 (R2 = 0.12, P < 0.0001), SRK/T (R2 = 0.11, P < 0.0001) and Haigis (R2 = 0.06, P < 0.0001). Conclusion Among 7 tested parameters, pre-ACD contribute little in ELP prediction. Formula consist of SSD, AL and SSW showed better accuracy than other formulas tested.

【 授权许可】

Unknown