期刊论文详细信息
International Journal of Molecular Sciences
Small Molecules Targeting Programmed Cell Death in Breast Cancer Cells
Sandra Maniam1  Subashani Maniam2 
[1] Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia;School of Science, STEM College, RMIT University, Melbourne, VIC 3001, Australia;
关键词: programmed cell death;    apoptosis;    autophagy;    breast cancer;    small molecule;   
DOI  :  10.3390/ijms22189722
来源: DOAJ
【 摘 要 】

Targeted chemotherapy has become the forefront for cancer treatment in recent years. The selective and specific features allow more effective treatment with reduced side effects. Most targeted therapies, which include small molecules, act on specific molecular targets that are altered in tumour cells, mainly in cancers such as breast, lung, colorectal, lymphoma and leukaemia. With the recent exponential progress in drug development, programmed cell death, which includes apoptosis and autophagy, has become a promising therapeutic target. The research in identifying effective small molecules that target compensatory mechanisms in tumour cells alleviates the emergence of drug resistance. Due to the heterogenous nature of breast cancer, various attempts were made to overcome chemoresistance. Amongst breast cancers, triple negative breast cancer (TNBC) is of particular interest due to its heterogeneous nature in response to chemotherapy. TNBC represents approximately 15% of all breast tumours, however, and still has a poor prognosis. Unlike other breast tumours, signature targets lack for TNBCs, causing high morbidity and mortality. This review highlights several small molecules with promising preclinical data that target autophagy and apoptosis to induce cell death in TNBC cells.

【 授权许可】

Unknown   

  文献评价指标  
  下载次数:0次 浏览次数:0次