New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles

Molecules

Roman A. Akasov¹  Andrey F. Mironov²  Maria E. Nikolaeva²  Mikhail A. Maslov²  Andrey V. Nechaev²  Elena V. Shmendel² 

[1] Federal Scientific Research Centre “Crystallography and Photonics” of RAS, 59 Leninsky Ave., 119333 Moscow, Russia;Lomonosov Institute of Fine Chemical Technologies, MIREA—Russian Technological University, 86 Vernadsky Ave., 119571 Moscow, Russia;

关键词: upconverting nanoparticles;    PEG-lipids;    surface modification;   

DOI  :  10.3390/molecules27092763

来源: DOAJ

【 摘 要 】

Upconverting nanoparticles have unique spectral and photophysical properties that make them suitable for development of theranostics for imaging and treating large and deep-seated tumors. Nanoparticles based on NaYF₄ crystals doped with lanthanides Yb³⁺ and Er³⁺ were obtained by the high-temperature decomposition of trifluoroacetates in oleic acid and 1-octadecene. Such particles have pronounced hydrophobic properties. Therefore, to obtain stable dispersions in aqueous media for the study of their properties in vivo and in vitro, the polyethylene glycol (PEG)-glycerolipids of various structures were obtained. To increase the circulation time of PEG-lipid coated nanoparticles in the bloodstream, long-chain substituents are needed to be attached to the glycerol backbone using ether bonds. To prevent nanoparticle aggregation, an L-cysteine-derived negatively charged carboxy group should be included in the lipid molecule.

【 授权许可】

Unknown