Electrospun Polyethylene Terephthalate Nanofibers Loaded with Silver Nanoparticles: Novel Approach in Anti-Infective Therapy

Journal of Clinical Medicine

AlinaMaria Holban¹  BogdanStefan Vasile¹  Ecaterina Andronescu¹  Cristina Chircov¹  AlexandruMihai Grumezescu¹  Anton Ficai¹  AlexandraElena Stoica¹  Anca Hermenean¹  Mihnea-Ștefan Dima-Bălcescu²  MarianaCarmen Chifiriuc³  Hildegard Herman⁴  Sami Gharbia⁴  Cornel Baltă⁴  Marcel Roșu⁴ 

[1] Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 060042 Bucharest, Romania;Faculty of Engineering in Foreign Languages, University Politehnica of Bucharest, 060042 Bucharest, Romania;ICUB, Research Institute of Bucharest University, University of Bucharest, 030018 Bucharest, Romania;Institute of Life Sciences, Vasile Goldis Western University of Arad, 310414 Arad, Romania;

关键词: polyethylene terephthalate;    PET;    silver nanoparticles;    electrospinning;    nanofibers;    antimicrobial agents;    biocompatibility;   

DOI  :  10.3390/jcm8071039

来源: DOAJ

【 摘 要 】

Polyethylene terephthalate (PET) is a major pollutant polymer, due to its wide use in food packaging and fiber production industries worldwide. Currently, there is great interest for recycling the huge amount of PET-based materials, derived especially from the food and textile industries. In this study, we applied the electrospinning technique to obtain nanostructured fibrillary membranes based on PET materials. Subsequently, the recycled PET networks were decorated with silver nanoparticles through the chemical reduction method for antimicrobial applications. After the characterization of the materials in terms of crystallinity, chemical bonding, and morphology, the effect against Gram-positive and Gram-negative bacteria, as well as fungal strains, was investigated. Furthermore, in vitro and in vivo biocompatibility tests were performed in order to open up potential biomedical applications, such as wound dressings or implant coatings. Silver-decorated fibers showed lower cytotoxicity and inflammatory effects and increased antibiofilm activity, thus highlighting the potential of these systems for antimicrobial purposes.

【 授权许可】

Unknown