Pre- and Perioperative Inflammatory Biomarkers in Older Patients Resected for Localized Colorectal Cancer: Associations with Complications and Prognosis

Cancers

Stig Egil Bojesen¹  Ib Jarle Christensen²  Hans Jørgen Nielsen²  Cecilia Margareta Lund³  Troels Gammeltoft Dolin³  Julia Sidenius Johansen³  Astrid Zedlitz Johansen⁴  Benny Vittrup Jensen⁴  Dorte Lisbeth Nielsen⁴  Mads Falk Klein⁵  Henrik Loft Jakobsen⁵ 

[1] Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark;Department of Gastrointestinal Surgery, Copenhagen University Hospital, DK-2650 Hvidovre, Denmark;Department of Medicine, Copenhagen University Hospital, DK-2730 Herlev, Denmark;Department of Oncology, Copenhagen University Hospital, DK-2730 Herlev, Denmark;Department of Surgery, Copenhagen University Hospital, DK-2730 Herlev, Denmark;

关键词: ageing;    CRP;    colorectal cancer;    complications;    inflammation;    IL-6;   

DOI  :  10.3390/cancers14010161

来源: DOAJ

【 摘 要 】

The association between pre- and perioperative inflammatory biomarkers, major complications, and survival rates after resection of colorectal cancer (CRC) in older patients is largely unknown. The aim was to investigate age-dependent differences in these associations. Serum CRP, IL-6, and YKL-40 were measured preoperatively and on the first and second day after resection of CRC (stages I–III) in 210 older (≥70 years) and 191 younger patients (<70 years). The results from the complications was presented as an odds ratio (OR, with a 95% confidence interval (CI)) with logistic regression. Results from the mortality rates were presented as a hazard ratio (HR, with a 95% CI) using Cox proportional hazards regression. The preoperative inflammatory biomarkers were higher in the older vs. the younger patients. The risk of complications was increased in older patients with a high preoperative CRP (OR = 1.25, 95% CI 1.03–1.53), IL-6 (OR = 1.57, 95% CI 1.18–2.08), and YKL-40 (OR = 1.66, 95% CI 1.20–2.28), but not in younger patients. Mortality was higher in younger patients with high preoperative YKL-40 (HR = 1.66, 95% CI 1.06–2.60). This was not found in older patients. Elevated preoperative inflammatory biomarkers among older patients were associated with an increased risk of complications, but not mortality. Preoperative inflammatory biomarkers may be useful in assessing the risk of a complicated surgical course in older patients with CRC.

【 授权许可】

Unknown