High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D

Bioactive Materials

Silvia Galli¹  Björn Wiese¹  D.C. Florian Wieland¹  Regine Willumeit-Römer²  Diana Krüger³  Philipp Heuser³  Ann Wennerberg³  Niccolò Peruzzi³  Julian Moosmann⁴  Berit Zeller-Plumhoff⁵ 

[1] Corresponding author.;Deutsches Elektronen-Synchrotron (DESY), Notkestrasse 85, 22607, Hamburg, Germany;Institute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Max-Planck-Str. 1, Geesthacht, 21502, Germany;Lund University, Department of Clinical Sciences Lund, Medical Radiation Physics, Barngatan 4, 22242, Lund, Sweden;University of Malmö, Faculty of Odontology, Department of Prosthodontics, Carl Gustafs väg 34, Klerken, 20506, Malmö, Sweden;

关键词: Magnesium alloys;    Biodegradable implant;    Micro-computed tomography degradation rate;    Degradation homogeneity;    Ex vivo imaging;    Ex vivo histology;   

DOI  :  

来源: DOAJ

【 摘 要 】

Biodegradable magnesium (Mg) alloys can revolutionize osteosynthesis, because they have mechanical properties similar to those of the bone, and degrade over time, avoiding the need of removal surgery. However, they are not yet routinely applied because their degradation behavior is not fully understood.In this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium (Gd) at high resolution.Mg-5Gd and Mg-10Gd screws were inserted in rat tibia for 4, 8 and 12 weeks. Afterward, the degradation rate and degradation homogeneity, as well as bone-to-implant interface, were studied with synchrotron radiation micro computed tomography and histology. Titanium (Ti) and polyether ether ketone (PEEK) were used as controls material to evaluate osseointegration.Our results showed that Mg-5Gd degraded faster and less homogeneously than Mg-10Gd. Both alloys gradually form a stable degradation layer at the interface and were surrounded by new bone tissue. The results were correlated to in vitro data obtained from the same material and shape. The average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for PEEK. The results suggest that both Mg-xGd alloys are suitable as materials for bone implants.

【 授权许可】

Unknown