The Regulatory Mechanisms and Therapeutic Potential of MicroRNAs: From Chronic Pain to Morphine Tolerance

Frontiers in Molecular Neuroscience

Zhao Dai¹  Haichen Chu¹  Yongxin Liang¹  Ying Yan¹  Xueying Zhang¹  Jiahai Ma² 

[1] Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, China;Department of Anesthesiology, The Affiliated Yantai Yuhuangding Hospital, Qingdao University, Qingdao, China;

关键词: microRNA;    chronic pain;    morphine tolerance;    microglia;    bone cancer pain;   

DOI  :  10.3389/fnmol.2018.00080

来源: DOAJ

【 摘 要 】

Chronic pain, including cancer-related pain, is a pain condition often caused by inflammation or dysfunctional nerves. Chronic pain treatment poses a significant health care challenge, where opioids especially morphine are widely used and patients often develop tolerance over time with aggravated pain. microRNA (miRNA) is known to play important roles in regulating gene expressions in the nervous system to affect neuronal network plasticity related to algogenesis and the developing of morphine tolerance. In this article, we reviewed studies conducted in rodent animal models investigating the mechanisms of miRNAs regulation in chronic pain with different phenotypes and morphine tolerance. In addition, the potential of targeting miRNAs for chronic pain and morphine tolerance treatment is also reviewed. Finally, we point out the directions of the future research in chronic pain and morphine tolerance.

【 授权许可】

Unknown