Medicinal Plants as a Potential and Successful Treatment Option in the Context of Atherosclerosis

Frontiers in Pharmacology

Ping-Yen Liu¹  Alexander N. Orekhov⁵  Alexander M. Markin⁶  Nikita G. Nikiforov⁷  Igor A. Sobenin⁷  Vasily N. Sukhorukov⁷  Tatiana V. Kirichenko⁷  Gjumrakch Aliev⁸  Vadim V. Tarasov⁹ 

[1]Division of Cardiology, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan

[2]GALLY International Research Institute, San Antonio, TX, United States

[3]Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

[4]Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russia

[5]Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Moscow, Russia

[6]Laboratory of Infection Pathology and Molecular Microecology, Research Institute of Human Morphology, Moscow, Russia

[7]Laboratory of Medical Genetics, National Medical Research Center of Cardiology, Moscow, Russia

[8]Laboratory of Molecular Pathology, Research Institute of Human Morphology, Moscow, Russia

[9]Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia

关键词: medicinal plants;    atherosclerosis;    cardiovascular risk;    anti-atherosclerotic mechanisms;    carotid IMT;   

DOI  :  10.3389/fphar.2020.00403

来源: DOAJ

【 摘 要 】

Atherosclerosis is a chronic multifactorial disease characterized by mainly changes of blood lipids profile and inflammation in vessel wall. The cardiovascular disease based on atherosclerosis is currently the leading cause of mortality in developed countries. Therefore, timely prevention and therapy of atherosclerosis are able to reduce the risk of the development of its clinical manifestations. Anti-atherosclerotic activity of medicinal plants mainly appears in their multiple effects such as anti-inflammatory, antioxidant, anti-atherogenic, hypotensive, lipid-lowering, anti-thrombotic. Moreover, most of medicinal plants are characterized by their pleiotropic anti-atherosclerotic action. In addition, the medicinal plants-derived pharmacological substances and/or compounds are characterized by relative safety and fewer side effects that allows considering them as one of potential anti-atherosclerotic effective agents. The direct anti-atherosclerotic effect of some medicinal plants was confirmed in clinical trials of carotid Intima-media thickness (IMT) progression during long-term medication with medicinal plants. This review attempted to determine the current status of the databases PubMed and Scopus (until November, 2019) to investigate the medicinal plants possessing anti-atherosclerotic activity in experimental and clinical studies.

【 授权许可】

Unknown