Frontiers in Molecular Neuroscience | |
Oncomodulin: The Enigmatic Parvalbumin Protein | |
Dwayne D. Simmons1  Timothy J. Reynolds1  Leslie K. Climer3  Andrew M. Cox3  | |
[1] Biomedical Sciences Program, Baylor University, Waco, TX, United States;Department of Biology, Baylor University, Waco, TX, United States;Department of Psychology and Neuroscience, Baylor University, Waco, TX, United States; | |
关键词: EF-hand Ca-binding protein ++; cochlea; hair cell; macrophage; beta parvalbumin; phylogeneticanalysis; | |
DOI : 10.3389/fnmol.2019.00235 | |
来源: DOAJ |
【 摘 要 】
EF-hand Ca2+-binding protein family members, α- and β-parvalbumins have been studied for decades. Yet, considerable information is lacking distinguishing functional differences between mammalian α-parvalbumin (PVALB) and oncomodulin (OCM), a branded β-parvalbumin. Herein, we provide an overview detailing the current body of work centered around OCM as an EF-Hand Ca2+-binding protein and describe potential mechanisms of OCM function within the inner ear and immune cells. Additionally, we posit that OCM is evolutionarily distinct from PVALB and most other β-parvalbumins. This review summarizes recent studies pertaining to the function of OCM and emphasizes OCM as a parvalbumin possessing a unique cell and tissue distribution, Ca2+ buffering capacity and phylogenetic origin.
【 授权许可】
Unknown