Oncomodulin: The Enigmatic Parvalbumin Protein

Frontiers in Molecular Neuroscience

Dwayne D. Simmons¹  Timothy J. Reynolds¹  Leslie K. Climer³  Andrew M. Cox³ 

[1] Biomedical Sciences Program, Baylor University, Waco, TX, United States;Department of Biology, Baylor University, Waco, TX, United States;Department of Psychology and Neuroscience, Baylor University, Waco, TX, United States;

关键词: EF-hand Ca-binding protein ++;    cochlea;    hair cell;    macrophage;    beta parvalbumin;    phylogeneticanalysis;   

DOI  :  10.3389/fnmol.2019.00235

来源: DOAJ

【 摘 要 】

EF-hand Ca2+-binding protein family members, α- and β-parvalbumins have been studied for decades. Yet, considerable information is lacking distinguishing functional differences between mammalian α-parvalbumin (PVALB) and oncomodulin (OCM), a branded β-parvalbumin. Herein, we provide an overview detailing the current body of work centered around OCM as an EF-Hand Ca2+-binding protein and describe potential mechanisms of OCM function within the inner ear and immune cells. Additionally, we posit that OCM is evolutionarily distinct from PVALB and most other β-parvalbumins. This review summarizes recent studies pertaining to the function of OCM and emphasizes OCM as a parvalbumin possessing a unique cell and tissue distribution, Ca2+ buffering capacity and phylogenetic origin.

【 授权许可】

Unknown