Modulation of Serotonin Receptors in Neurodevelopmental Disorders: Focus on 5-HT7 Receptor

Molecules

Jieon Lee¹  Diana Avramets¹  Byungsun Jeon¹  Hyunah Choo¹ 

[1] Brain Science Institute, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 02792, Korea;

关键词: serotonin receptor;    5-HT₇R;    neurodevelopmental disorders;    autism spectrum disorder;    fragile X syndrome;    Rett syndrome;   

DOI  :  10.3390/molecules26113348

来源: DOAJ

【 摘 要 】

Since neurodevelopmental disorders (NDDs) influence more than 3% of children worldwide, there has been intense investigation to understand the etiology of disorders and develop treatments. Although there are drugs such as aripiprazole, risperidone, and lurasidone, these medications are not cures for the disorders and can only help people feel better or alleviate their symptoms. Thus, it is required to discover therapeutic targets in order to find the ultimate treatments of neurodevelopmental disorders. It is suggested that abnormal neuronal morphology in the neurodevelopment process is a main cause of NDDs, in which the serotonergic system is emerging as playing a crucial role. From this point of view, we noticed the correlation between serotonin receptor subtype 7 (5-HT₇R) and NDDs including autism spectrum disorder (ASD), fragile X syndrome (FXS), and Rett syndrome (RTT). 5-HT₇R modulators improved altered behaviors in animal models and also affected neuronal morphology via the 5-HT₇R/G₁₂ signaling pathway. Through the investigation of recent studies, it is suggested that 5-HT₇R could be a potential therapeutic target for the treatment of NDDs.

【 授权许可】

Unknown