CTNNB1 in neurodevelopmental disorders

Frontiers in Psychiatry

Psychiatry

Tong Ye¹  Weihong Song¹  Wenting Zhuang¹  Tao Tan²  Wei Wang² 

[1] Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Wenzhou Medical University, Wenzhou, China;Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Wenzhou Medical University, Wenzhou, China;Department of Neuroscience, Baylor College of Medicine, Houston, TX, United States;

关键词: CTNNB1;    -catenin;    neurodevelopmental disorders;    intellectual disability;    autism spectrum disorder;    schizophrenia;   

DOI  :  10.3389/fpsyt.2023.1143328

 received in 2023-01-12, accepted in 2023-02-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

CTNNB1 is the gene that encodes β-catenin which acts as a key player in the Wnt signaling pathway and regulates cellular homeostasis. Most CTNNB1-related studies have been mainly focused on its role in cancer. Recently, CTNNB1 has also been found involved in neurodevelopmental disorders (NDDs), such as intellectual disability, autism, and schizophrenia. Mutations of CTNNB1 lead to the dysfunction of the Wnt signaling pathway that regulates gene transcription and further disturbs synaptic plasticity, neuronal apoptosis, and neurogenesis. In this review, we discuss a wide range of aspects of CTNNB1 and its physiological and pathological functions in the brain. We also provide an overview of the most recent research regarding CTNNB1 expression and its function in NDDs. We propose that CTNNB1 would be one of the top high-risk genes for NDDs. It could also be a potential therapeutic target for the treatment of NDDs.

【 授权许可】

Unknown   
Copyright © 2023 Zhuang, Ye, Wang, Song and Tan.