Acoustic Microfluidic Separation Techniques and Bioapplications: A Review

Micromachines

Mengren Wu¹  Yuan Gao¹  Jie Xu¹  Yang Lin² 

[1] Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA;Department of Mechanical, Industrial and Systems Engineering, University of Rhode Island, Kingston, RI 02881, USA;

关键词: microfluidics;    acoustic separation techniques;    bioapplications;    BAW;    SAW;   

DOI  :  10.3390/mi11100921

来源: DOAJ

【 摘 要 】

Microfluidic separation technology has garnered significant attention over the past decade where particles are being separated at a micro/nanoscale in a rapid, low-cost, and simple manner. Amongst a myriad of separation technologies that have emerged thus far, acoustic microfluidic separation techniques are extremely apt to applications involving biological samples attributed to various advantages, including high controllability, biocompatibility, and non-invasive, label-free features. With that being said, downsides such as low throughput and dependence on external equipment still impede successful commercialization from laboratory-based prototypes. Here, we present a comprehensive review of recent advances in acoustic microfluidic separation techniques, along with exemplary applications. Specifically, an inclusive overview of fundamental theory and background is presented, then two sets of mechanisms underlying acoustic separation, bulk acoustic wave and surface acoustic wave, are introduced and discussed. Upon these summaries, we present a variety of applications based on acoustic separation. The primary focus is given to those associated with biological samples such as blood cells, cancer cells, proteins, bacteria, viruses, and DNA/RNA. Finally, we highlight the benefits and challenges behind burgeoning developments in the field and discuss the future perspectives and an outlook towards robust, integrated, and commercialized devices based on acoustic microfluidic separation.

【 授权许可】

Unknown