Low Dietary Magnesium and Overweight/Obesity in a Mediterranean Population: A Detrimental Synergy for the Development of Hypertension. The SUN Project

Nutrients

Liz Ruiz-Estigarribia¹  Carmen Sayón-Orea¹  Alfredo Gea¹  MiguelA. Martínez-González¹  Miguel Ruiz-Canela¹  LigiaJ. Dominguez²  Mario Barbagallo²  Ujue Fresán³ 

[1] Department of Preventive Medicine and Public Health, University of Navarra-IDISNA, 31008 Pamplona, Spain;Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90127 Palermo, Italy;eHealth Group, ISGlobal, 08036 Barcelona, Spain;

关键词: magnesium;    hypertension;    obesity;    overweight;    diet;    cohort studies;   

DOI  :  10.3390/nu13010125

来源: DOAJ

【 摘 要 】

Hypertension is the strongest independent modifiable risk factor for cardiovascular disease. We aimed to investigate the association of magnesium intake with incident hypertension in a Mediterranean population, and the potential modification of this association by body mass index BMI. We assessed 14,057 participants of the SUN (Seguimiento Universidad de Navarra) prospective cohort (67.0% women) initially free of hypertension. At baseline, a validated 136-item food frequency questionnaire was administered. We used Cox models adjusted for multiple socio-demographic, anthropometric, and lifestyle factors, and prevalent conditions present at baseline. Among a mean 9.6 years of follow-up we observed 1406 incident cases of medically diagnosed hypertension. An inverse association in multivariable-adjusted models was observed for progressively higher magnesium intake up to 500 mg/d vs. intake < 200 mg/d, which was greater among those with a BMI > 27 kg/m². Lean participants with magnesium intake < 200 mg/d vs. >200 mg/d also had a higher risk of incident hypertension. Adherence to the Mediterranean diet did not modify these associations. In conclusion, dietary magnesium intake < 200 mg/d was independently associated with a higher risk of developing hypertension in a Mediterranean cohort, stronger for overweight/obese participants. Our results emphasize the importance of encouraging the consumption of magnesium-rich foods (vegetables, nuts, whole cereals, legumes) in order to prevent hypertension.

【 授权许可】

Unknown